From time to time, I make a mistake by failing to keep up with the primary scientific literature as closely as I should. If I had been on my grind, I would have noticed that another Zika structure was published in Science at around the same time as the Nature structure that I blogged about earlier. The group that put together this structure also compared the Zika particle to related viruses, this time choosing to focus on a region of the viral protein coat that is especially dissimilar to related viruses. The authors go on to suggest that this region of the coat may be involved in attaching to host cells, which could explain how transmissible Zika is compared to its relatives.
(Image credit: Kostyuchenko et al. (2016) Nature.)
Update (4/27/2016): Science also published a Zika structure, drawing complementary conclusions from it. I thought it would be a good idea to post a small blurb about it here.
A group in Singapore published a structure of the Zika virus particle in Nature on Wednesday. Zika, which the Centers for Disease Control recently concluded is responsible for birth defects in children of infected mothers, has become a growing public health concern.
Victor A. Kostyuchenko and his colleagues at the Duke-National University of Singapore Medical School used cryo-electron microscopy to see the structure of Zika particles incubated at different temperatures. Importantly, the scientists found that the Zika particle is stable over a broader range of temperatures than other related viruses. On a practical level, this could mean that the virus is more transmissible than related viruses, and may be more challenging to control.
Virus particles are simply genetic material–either DNA or RNA–surrounded by a protein coat that protects and transports the genetic material. When the protein coat comes into contact with a susceptible cell, the virus can inject its genetic material into the host. The virus then uses its own genetic material to take over the cell’s own protein-producing machinery in order to produce more viruses. Eventually, those new viruses will be released and go on to infect other cells.
The authors note that their structural model can allow others to find drugs that may destabilize the virus. The hardiness of the Zika particle is almost certainly due to a tough protein coat, but certain drugs may make that protein coat more susceptible to degradation at higher temperatures or other harsh environments. All of this can be used to help stem the transmission of the virus.
For more information, check out the article at Nature: http://www.nature.com/nature/journal/vnfv/ncurrent/full/nature17994.html